Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD(+) Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans

Temporal developmental progression is highly coordinated in Caenorhabditis elegans. However, loss of nicotinamidase PNC-1 activity slows reproductive development, uncoupling it from its typical progression relative to the soma. Using LC/MS we demonstrate that pnc-1 mutants do not salvage the nicotin...

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Udgivet i:J Biol Chem
Main Authors: Wang, Wenqing, McReynolds, Melanie R., Goncalves, Jimmy F., Shu, Muya, Dhondt, Ineke, Braeckman, Bart P., Lange, Stephanie E., Kho, Kelvin, Detwiler, Ariana C., Pacella, Marisa J., Hanna-Rose, Wendy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646267/
https://ncbi.nlm.nih.gov/pubmed/26350462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662916
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