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Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain

Acids 9 a–f as possible bivalent ligands designed as a structural combination of opioid μ-agonist (Fentanyl) and NSAID (Indomethacin) activities and produced compounds which were tested as analgesics. The obtained series of compounds exhibits low affinity and activity both at opioid receptors and as...

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Main Authors: Vardanyan, Ruben, Vijay, Gokhale, Nichol, Gary S., Liu, Lu, Kumarasinghe, Isuru, Davis, Peg, Vanderah, Todd, Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759397/
https://ncbi.nlm.nih.gov/pubmed/19540763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.05.065
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