Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain

The conventional design of high affinity drugs targeted to a single molecule has not resulted in clinically useful therapies for pain relief. Recent reviews have suggested that newly designed analgesic drugs should incorporate multiple targets. The distributions of cholecystokinin (CCK) and CCK rece...

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Bibliographische Detailangaben
Hauptverfasser: Hanlon, Katherine E., Herman, Dave S., Agnes, Richard S., Largent-Milnes, Tally M., Kumarasinghe, Isuru R., Ma, Sho W., Guo, Wenhong, Lee, Yeon-Sun, Ossipov, Michael H., Hruby, Victor J., Lai, Josephine, Porreca, Frank, Vanderah, Todd W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105124/
https://ncbi.nlm.nih.gov/pubmed/21550594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2011.04.024
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