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Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain
Acids 9 a–f as possible bivalent ligands designed as a structural combination of opioid μ-agonist (Fentanyl) and NSAID (Indomethacin) activities and produced compounds which were tested as analgesics. The obtained series of compounds exhibits low affinity and activity both at opioid receptors and as...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2759397/ https://ncbi.nlm.nih.gov/pubmed/19540763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.05.065 |
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