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Checkpoint signaling from a single DNA interstrand crosslink
DNA interstrand crosslinks (ICLs) are the most toxic lesions induced by chemotherapeutic agents such as Mitomycin C and Cisplatin. By covalently linking both DNA strands, ICLs prevent DNA melting, transcription, and replication. Studies on ICL signaling and repair have been limited because these dru...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756577/ https://ncbi.nlm.nih.gov/pubmed/19748363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.08.014 |
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