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Replication-Independent Repair of DNA Interstrand Crosslinks

DNA interstrand crosslinks (ICLs) are cytotoxic lesions that covalently link opposite strands of the DNA helix and block DNA unwinding. ICLs are repaired during and outside S phase, and replication-independent ICL repair (RIR) is critical to maintain genomic integrity and to allow transcription in n...

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Detalhes bibliográficos
Main Authors: Williams, Hannah L., Gottesman, Max E., Gautier, Jean
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666337/
https://ncbi.nlm.nih.gov/pubmed/22658724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.05.001
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