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Checkpoint signaling from a single DNA interstrand crosslink

DNA interstrand crosslinks (ICLs) are the most toxic lesions induced by chemotherapeutic agents such as Mitomycin C and Cisplatin. By covalently linking both DNA strands, ICLs prevent DNA melting, transcription, and replication. Studies on ICL signaling and repair have been limited because these dru...

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Bibliografske podrobnosti
Main Authors: Ben-Yehoyada, Merav, Wang, Lily C., Kozekov, Ivan D., Rizzo, Carmelo J., Gottesman, Max E., Gautier, Jean
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756577/
https://ncbi.nlm.nih.gov/pubmed/19748363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.08.014
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