Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components

New World monkeys of the genus Aotus synthesize a fusion protein (AoT5Cyp) containing tripartite motif-containing 5 (TRIM5) and cyclophilin A (CypA) that potently blocks HIV-1 infection. We attempted to generate a human HIV-1 inhibitor modeled after AoT5Cyp, by fusing human CypA to human TRIM5 (hT5C...

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Detalhes bibliográficos
Main Authors: Neagu, Martha R., Ziegler, Patrick, Pertel, Thomas, Strambio-De-Castillia, Caterina, Grütter, Christian, Martinetti, Gladys, Mazzucchelli, Luca, Grütter, Markus, Manz, Markus G., Luban, Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752079/
https://ncbi.nlm.nih.gov/pubmed/19741300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39354
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