An Invariant Surface Patch on the TRIM5α PRYSPRY Domain Is Required for Retroviral Restriction but Dispensable for Capsid Binding

TRIM5α is a retrovirus restriction factor in the host cell cytoplasm that blocks infection before provirus establishment. Restriction activity requires capsid (CA)-specific recognition by the PRYSPRY domain of TRIM5α. To better understand the restriction mechanism, nine charge-cluster-to-triple-alan...

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Detalhes bibliográficos
Main Authors: Sebastian, Sarah, Grütter, Christian, de Castillia, Caterina Strambio, Pertel, Thomas, Olivari, Silvia, Grütter, Markus G., Luban, Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655600/
https://ncbi.nlm.nih.gov/pubmed/19153241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00432-08
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