TRIM5 is an innate immune sensor for the retrovirus capsid lattice

TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by HIV-1 and other retroviruses immediately following virus invasion of the target cell cytoplasm1,2. Antiviral potency correlates with TRIM5 avidity for the retrovirion capsid lattice3,4 and several reports indicate that TRIM5 play...

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Main Authors: Pertel, Thomas, Hausmann, Stéphane, Morger, Damien, Züger, Sara, Guerra, Jessica, Lascano, Josefina, Reinhard, Christian, Santoni, Federico, Uchil, Pradeep D., Chatel, Laurence, Bisiaux, Aurelie, Albert, Matthew, Strambio-De-Castillia, Caterina, Mothes, Walther, Pizzato, Massimo, Grütter, Markus, Luban, Jeremy
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081621/
https://ncbi.nlm.nih.gov/pubmed/21512573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09976
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