The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5α

Rhesus TRIM5α (rhTRIM5α) potently restricts replication of human immunodeficiency virus type 1 (HIV-1). Restriction is mediated through direct binding of the C-terminal B30.2 domain of TRIM5α to the assembled HIV-1 capsid core. This host-pathogen interaction involves multiple capsid molecules within...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Morger, Damien, Zosel, Franziska, Bühlmann, Martin, Züger, Sara, Mittelviefhaus, Maximilian, Schuler, Benjamin, Luban, Jeremy, Grütter, Markus G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Structure and Assembly
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809731/
https://ncbi.nlm.nih.gov/pubmed/29237846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01541-17
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