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TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling

Host restriction factor TRIM5 inhibits retroviral transduction in a species-specific manner by binding to and destabilizing the retroviral capsid lattice before reverse transcription is completed. However, the restriction mechanism may not be that simple since TRIM5 E3 ubiquitin ligase activity, the...

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Publicat a:J Virol
Autors principals: Lascano, Josefina, Uchil, Pradeep D., Mothes, Walther, Luban, Jeremy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702541/
https://ncbi.nlm.nih.gov/pubmed/26468522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02496-15
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