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TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling
Host restriction factor TRIM5 inhibits retroviral transduction in a species-specific manner by binding to and destabilizing the retroviral capsid lattice before reverse transcription is completed. However, the restriction mechanism may not be that simple since TRIM5 E3 ubiquitin ligase activity, the...
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| Publicado no: | J Virol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4702541/ https://ncbi.nlm.nih.gov/pubmed/26468522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02496-15 |
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