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TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling

Host restriction factor TRIM5 inhibits retroviral transduction in a species-specific manner by binding to and destabilizing the retroviral capsid lattice before reverse transcription is completed. However, the restriction mechanism may not be that simple since TRIM5 E3 ubiquitin ligase activity, the...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Lascano, Josefina, Uchil, Pradeep D., Mothes, Walther, Luban, Jeremy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702541/
https://ncbi.nlm.nih.gov/pubmed/26468522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02496-15
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