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Cyclophilin A protects HIV-1 from restriction by human TRIM5α
The HIV-1 capsid (CA) protein lattice encases viral genomic RNA and regulates steps essential to target cell invasion(1). Cyclophilin A (CypA) has interacted with the CA of lentiviruses related to HIV-1 for millions of years(2–7). Disruption of the CA-CypA interaction decreases HIV-1 infectivity in...
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| Publicado no: | Nat Microbiol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6879858/ https://ncbi.nlm.nih.gov/pubmed/31636416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0592-5 |
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