Inhibition of Siderophore Biosynthesis by 2-Triazole Substituted Analogues of 5’-O-[N-(Salicyl)sulfamoyl]adenosine: Antibacterial Nucleosides Effective Against Mycobacterium tuberculosis

The synthesis, biochemical, and biological evaluation of a systematic series of 2-triazole derivatives of 5’-O-[N-(salicyl)sulfamoyl]adenosine (Sal-AMS) are described as inhibitors of aryl acid adenylating enzymes (AAAE) involved in siderophore biosynthesis by Mycobacterium tuberculosis. Structure a...

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Main Authors: Gupte, Amol, Boshoff, Helena I., Wilson, Daniel J., Neres, João, Labello, Nicholas P., Somu, Ravindranadh V., Xing, Chengguo, Barry, Clifton E., Aldrich, Courtney C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750848/
https://ncbi.nlm.nih.gov/pubmed/19053762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8008037
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