Inhibition of Siderophore Biosynthesis in Mycobacterium tuberculosis with Nucleoside Bisubstrate Analogues: Structure–Activity Relationships of the Nucleobase Domain of 5′-O-[N-(Salicyl)sulfamoyl]adenosine

5′-O-[N-(salicyl)sulfamoyl]adenosine (Sal-AMS) is a prototype for a new class of antitubercular agents that inhibit the aryl acid adenylating enzyme (AAAE) known as MbtA involved in biosynthesis of the mycobactins. Herein, we report the structure-based design, synthesis, biochemical, and biological...

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Autors principals: Neres, João, Labello, Nicholas P., Somu, Ravindranadh V., Boshoff, Helena I., Wilson, Daniel J., Vannada, Jagadeshwar, Chen, Liqiang, Barry, Clifton E., Bennett, Eric M., Aldrich, Courtney C.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800054/
https://ncbi.nlm.nih.gov/pubmed/18690677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800567v
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