Inhibition of Siderophore Biosynthesis in Mycobacterium tuberculosis with Nucleoside Bisubstrate Analogues: Structure–Activity Relationships of the Nucleobase Domain of 5′-O-[N-(Salicyl)sulfamoyl]adenosine

5′-O-[N-(salicyl)sulfamoyl]adenosine (Sal-AMS) is a prototype for a new class of antitubercular agents that inhibit the aryl acid adenylating enzyme (AAAE) known as MbtA involved in biosynthesis of the mycobactins. Herein, we report the structure-based design, synthesis, biochemical, and biological...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Neres, João, Labello, Nicholas P., Somu, Ravindranadh V., Boshoff, Helena I., Wilson, Daniel J., Vannada, Jagadeshwar, Chen, Liqiang, Barry, Clifton E., Bennett, Eric M., Aldrich, Courtney C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800054/
https://ncbi.nlm.nih.gov/pubmed/18690677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800567v
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi