2-Aryl-8-aza-3-deazaadenosine Analogues of 5’-O-[N-(Salicyl)sulfamoyl]adenosine: Nucleoside Antibiotics that Block Siderophore Biosynthesis in Mycobacterium tuberculosis

A series of 5’-O-[N-(salicyl)sulfamoyl]-2-aryl-8-aza-3-deazaadenosines were designed to block mycobactin biosynthesis in Mycobacterium tuberculosis (Mtb) through inhibition of the essential adenylating enzyme MbtA. The synthesis of the 2-aryl-8-aza-3-deazaadenosine nucleosides featured sequential co...

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發表在:Bioorg Med Chem
Main Authors: Krajczyk, Anna, Zeidler, Joanna, Januszczyk, Piotr, Dawadi, Surendra, Boshoff, Helena I., Barry, Clifton E., Ostrowski, Tomasz, Aldrich, Courtney C.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914392/
https://ncbi.nlm.nih.gov/pubmed/27265685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.05.037
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