5′-O-[(N-Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Adenylation Enzyme Required for Siderophore Biosynthesis of the Mycobactins

A study of the structure–activity relationships (SAR) of 5′-O-[N-(Salicyl)sulfamoyl]adenosine (6), a potent inhibitor of the bifunctional enzyme salicyl-AMP ligase (MbtA, encoded by the gene Rv2384) in Mycobacterium tuberculosis, is described, targeting the salicyl moiety. A systematic series of ana...

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Detalhes bibliográficos
Main Authors: Qiao, Chunhua, Gupte, Amol, Boshoff, Helena I., Wilson, Daniel J., Bennett, Eric M., Somu, Ravindranadh V., Barry, Clifton E., Aldrich, Courtney C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2539069/
https://ncbi.nlm.nih.gov/pubmed/17967002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070905o
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