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Synthesis of deuterium-labelled 5′-O-[N-(Salicyl)sulfamoyl]adenosine (Sal-AMS-d(4)) as an internal standard for quantitation of Sal-AMS

5′-O-[N-(Salicyl)sulfamoyl]adenosine (Sal-AMS, 1) is a potent inhibitor of the bifunctional enzyme salicyl-AMP ligase in Mycobacterium tuberculosis. This inhibitor acts by disrupting the biosynthesis of the mycobactin siderophores that are essential for the process of iron acquisition. To aid with i...

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Библиографические подробности
Главные авторы: Gupte, Amol, Subramanian, Murali, Remmel, Rory P., Aldrich, Courtney C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367327/
https://ncbi.nlm.nih.gov/pubmed/19050743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.1490
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