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Heat and mass transfer scale-up issues during freeze drying: II. Control and characterization of the degree of supercooling

This study aims to investigate the effect of the ice nucleation temperature on the primary drying process using an ice fog technique for temperature-controlled nucleation. In order to facilitate scale up of the freeze-drying process, this research seeks to find a correlation of the product resistanc...

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Detalhes bibliográficos
Main Authors: Rambhatla, Shailaja, Ramot, Roee, Bhugra, Chandan, Pikal, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750483/
https://ncbi.nlm.nih.gov/pubmed/15760055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/pt050458
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