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Reduced Pressure Ice Fog Technique for Controlled Ice Nucleation during Freeze-Drying

A method to achieve controlled ice nucleation during the freeze-drying process using an ice fog technique was demonstrated in an earlier report. However, the time required for nucleation was about 5 min, even though only one shelf was used, which resulted in Ostwald ripening (annealing) in some of t...

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Autors principals: Patel, Sajal M., Bhugra, Chandan, Pikal, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799604/
https://ncbi.nlm.nih.gov/pubmed/19937284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-009-9338-7
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