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Dynamically Driven Ligand Selectivity in Cyclic Nucleotide Binding Domains
One of the mechanisms that minimize the aberrant cross-talk between cAMP- and cGMP-dependent signaling pathways relies on the selectivity of cAMP binding domains (CBDs). For instance, the CBDs of two critical eukaryotic cAMP receptors, i.e. protein kinase A (PKA) and the exchange protein activated b...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2749143/ https://ncbi.nlm.nih.gov/pubmed/19403523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011700 |
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