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Dynamically Driven Ligand Selectivity in Cyclic Nucleotide Binding Domains

One of the mechanisms that minimize the aberrant cross-talk between cAMP- and cGMP-dependent signaling pathways relies on the selectivity of cAMP binding domains (CBDs). For instance, the CBDs of two critical eukaryotic cAMP receptors, i.e. protein kinase A (PKA) and the exchange protein activated b...

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Detalhes bibliográficos
Main Authors: Das, Rahul, Chowdhury, Somenath, Mazhab-Jafari, Mohammad T., SilDas, Soumita, Selvaratnam, Rajeevan, Melacini, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749143/
https://ncbi.nlm.nih.gov/pubmed/19403523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011700
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