Communication between Tandem cAMP Binding Domains in the Regulatory Subunit of Protein Kinase A-Iα as Revealed by Domain-silencing Mutations

Protein kinase A (PKA) is the main receptor for the universal cAMP second messenger. PKA is a tetramer with two catalytic (C) and two regulatory (R) subunits, each including two tandem cAMP binding domains, i.e. CBD-A and -B. Structural investigations of RIα have revealed that although CBD-A plays a...

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Main Authors: McNicholl, E. Tyler, Das, Rahul, SilDas, Soumita, Taylor, Susan S., Melacini, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865341/
https://ncbi.nlm.nih.gov/pubmed/20202931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105783
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