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The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR

The cyclic-AMP binding domain (CBD) is the central regulatory unit of exchange proteins activated by cAMP (EPAC). The CBD maintains EPAC in a state of auto-inhibition in the absence of the allosteric effector, cAMP. When cAMP binds to the CBD such auto-inhibition is released, leading to EPAC activat...

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Detalhes bibliográficos
Main Authors: Selvaratnam, Rajeevan, Mazhab-Jafari, Mohammad T., Das, Rahul, Melacini, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504058/
https://ncbi.nlm.nih.gov/pubmed/23185272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048707
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