Structure of the S5a:K48-linked diubiquitin complex and its interactions with Rpn13

Degradation by the proteasome typically requires substrate ubiquitination. Two ubiquitin receptors exist in the proteasome, S5a/Rpn10 and Rpn13. Whereas Rpn13 has only one ubiquitin-binding surface, S5a binds ubiquitin with two independent ubiquitin interacting motifs (UIMs). Here, we use NMR and an...

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Hauptverfasser: Zhang, Naixia, Wang, Qinghua, Ehlinger, Aaron, Randles, Leah, Lary, Jeffrey W., Kang, Yang, Haririnia, Aydin, Storaska, Andrew J., Cole, James L., Fushman, David, Walters, Kylie J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748877/
https://ncbi.nlm.nih.gov/pubmed/19683493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.06.010
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