PROFILING HUMAN ANDROGEN RECEPTOR MUTATIONS REVEALS TREATMENT EFFECTS IN A MOUSE MODEL OF PROSTATE CANCER

Gain of function mutations in the androgen receptor (AR) are found in prostate cancer and are implicated in the failure of hormone therapy. Most studies have emphasized the ligand binding domain (LBD) where mutations can create promiscuous receptors, but mutations in the N-terminal transactivation d...

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Bibliografiske detaljer
Main Authors: O’Mahony, Orla A., Steinkamp, Mara P., Albertelli, Megan A., Brogley, Michele, Rehman, Haniya, Robins, Diane M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748651/
https://ncbi.nlm.nih.gov/pubmed/19010817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0273
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