PROFILING HUMAN ANDROGEN RECEPTOR MUTATIONS REVEALS TREATMENT EFFECTS IN A MOUSE MODEL OF PROSTATE CANCER

Gain of function mutations in the androgen receptor (AR) are found in prostate cancer and are implicated in the failure of hormone therapy. Most studies have emphasized the ligand binding domain (LBD) where mutations can create promiscuous receptors, but mutations in the N-terminal transactivation d...

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Detalhes bibliográficos
Main Authors: O’Mahony, Orla A., Steinkamp, Mara P., Albertelli, Megan A., Brogley, Michele, Rehman, Haniya, Robins, Diane M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748651/
https://ncbi.nlm.nih.gov/pubmed/19010817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0273
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