Differential modulation of the androgen receptor for prostate cancer therapy depends on the DNA response element

Androgen receptor (AR) action is a hallmark of prostate cancer (PCa) with androgen deprivation being standard therapy. Yet, resistance arises and aberrant AR signaling promotes disease. We sought compounds that inhibited genes driving cancer but not normal growth and hypothesized that genes with con...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Kregel, Steven, Bagamasbad, Pia, He, Shihan, LaPensee, Elizabeth, Raji, Yemi, Brogley, Michele, Chinnaiyan, Arul, Cieslik, Marcin, Robins, Diane M
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
Gene regulation, Chromatin and Epigenetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229860/
https://ncbi.nlm.nih.gov/pubmed/32198885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa178
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