TREATMENT-DEPENDENT ANDROGEN RECEPTOR MUTATIONS IN PROSTATE CANCER EXPLOIT MULTIPLE MECHANISMS TO EVADE THERAPY

Mutations in the androgen receptor (AR) that enable activation by antiandrogens occur in hormone-refractory prostate cancer, suggesting mutant ARs are selected by treatment. To validate this hypothesis, we compared AR variants in metastases obtained by rapid autopsy of patients treated with flutamid...

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Detalhes bibliográficos
Main Authors: Steinkamp, Mara P., O'Mahony, Orla A., Brogley, Michele, Rehman, Haniya, LaPensee, Elizabeth W., Dhanasekaran, Saravana, Hofer, Matthias D., Kuefer, Rainer, Chinnaiyan, Arul, Rubin, Mark A., Pienta, Kenneth J., Robins, Diane M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765801/
https://ncbi.nlm.nih.gov/pubmed/19366804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3605
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