TREATMENT-DEPENDENT ANDROGEN RECEPTOR MUTATIONS IN PROSTATE CANCER EXPLOIT MULTIPLE MECHANISMS TO EVADE THERAPY

Mutations in the androgen receptor (AR) that enable activation by antiandrogens occur in hormone-refractory prostate cancer, suggesting mutant ARs are selected by treatment. To validate this hypothesis, we compared AR variants in metastases obtained by rapid autopsy of patients treated with flutamid...

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Главные авторы: Steinkamp, Mara P., O'Mahony, Orla A., Brogley, Michele, Rehman, Haniya, LaPensee, Elizabeth W., Dhanasekaran, Saravana, Hofer, Matthias D., Kuefer, Rainer, Chinnaiyan, Arul, Rubin, Mark A., Pienta, Kenneth J., Robins, Diane M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765801/
https://ncbi.nlm.nih.gov/pubmed/19366804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3605
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