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PROFILING HUMAN ANDROGEN RECEPTOR MUTATIONS REVEALS TREATMENT EFFECTS IN A MOUSE MODEL OF PROSTATE CANCER
Gain of function mutations in the androgen receptor (AR) are found in prostate cancer and are implicated in the failure of hormone therapy. Most studies have emphasized the ligand binding domain (LBD) where mutations can create promiscuous receptors, but mutations in the N-terminal transactivation d...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2748651/ https://ncbi.nlm.nih.gov/pubmed/19010817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0273 |
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