Interaction of the Androgen Receptor, ETV1, and PTEN Pathways in Mouse Prostate Varies with Pathological Stage and Predicts Cancer Progression

To examine the impact of common somatic mutations in prostate cancer (PCa) on androgen receptor (AR) signaling, mouse models were designed to perturb sequentially the AR, ETV1, and PTEN pathways. Mice with “humanized” AR (hAR) alleles that modified AR transcriptional strength by varying polyglutamin...

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Detalhes bibliográficos
Publicado no:Horm Cancer
Main Authors: Higgins, Jake, Brogley, Michele, Palanisamy, Nallasivam, Mehra, Rohit, Ittmann, Michael M., Li, Jun Z., Tomlins, Scott A., Robins, Diane M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414739/
https://ncbi.nlm.nih.gov/pubmed/25631336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12672-014-0215-9
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