Development of a Human Immunodeficiency Virus Type 1-Based Lentiviral Vector That Allows Efficient Transduction of both Human and Rhesus Blood Cells

Human immunodeficiency virus type 1 (HIV-1) vectors transduce rhesus blood cells poorly due to a species-specific block by TRIM5α and APOBEC3G, which target HIV-1 capsid and viral infectivity factor (Vif), respectively. We sought to develop a lentiviral vector capable of transducing both human and r...

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Main Authors: Uchida, Naoya, Washington, Kareem N., Hayakawa, Jun, Hsieh, Matthew M., Bonifacino, Aylin C., Krouse, Allen E., Metzger, Mark E., Donahue, Robert E., Tisdale, John F.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Assuntos:
Gene Delivery
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748003/
https://ncbi.nlm.nih.gov/pubmed/19625395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00357-09
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