TRIM5α Variations Influence Transduction Efficiency With Lentiviral Vectors in Both Human and Rhesus CD34(+) Cells In Vitro and In Vivo

Human immunodeficiency virus type 1 (HIV-1) vectors can transduce human hematopoietic stem cells (HSC), but transduction efficiency varies among individuals. The innate immune factor tripartite motif-containing protein 5α (TRIM5α) plays an important role for restriction of retroviral infection. In t...

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Hlavní autoři: Evans, Molly E, Kumkhaek, Chutima, Hsieh, Matthew M, Donahue, Robert E, Tisdale, John F, Uchida, Naoya
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916046/
https://ncbi.nlm.nih.gov/pubmed/24153115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.256
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