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Decitabine Suspends Human CD34(+) Cell Differentiation and Proliferation during Lentiviral Transduction

Efficient ex vivo transduction of hematopoietic stem cells (HSCs) is encumbered by differentiation which reduces engraftment. We hypothesized that inhibiting DNA methyltransferase with decitabine would block differentiation of transduced CD34(+) cells under cytokine stimulation and thus improve tran...

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Autors principals: Uchida, Naoya, Hsieh, Matthew M., Platner, Charlotte, Saunthararajah, Yogen, Tisdale, John F.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121241/
https://ncbi.nlm.nih.gov/pubmed/25089909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104022
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