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Decitabine Suspends Human CD34(+) Cell Differentiation and Proliferation during Lentiviral Transduction

Efficient ex vivo transduction of hematopoietic stem cells (HSCs) is encumbered by differentiation which reduces engraftment. We hypothesized that inhibiting DNA methyltransferase with decitabine would block differentiation of transduced CD34(+) cells under cytokine stimulation and thus improve tran...

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Bibliografiske detaljer
Main Authors: Uchida, Naoya, Hsieh, Matthew M., Platner, Charlotte, Saunthararajah, Yogen, Tisdale, John F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121241/
https://ncbi.nlm.nih.gov/pubmed/25089909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104022
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