Conformational detection of p53's oligomeric state by FlAsH Fluorescence

The p53 tumor suppressor protein is a critical checkpoint in prevention of tumor formation, and the function of p53 is dependent on proper formation of the active tetramer. In vitro studies have shown that p53 binds DNA most efficiently as a tetramer, though inactive p53 is predicted to be monomeric...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Webber, Tawnya M., Allen, Andrew C., Ma, Wai Kit, Molloy, Rhett G., Kettelkamp, Charisse N., Dow, Caitlin A., Gage, Matthew J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743378/
https://ncbi.nlm.nih.gov/pubmed/19393630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.04.073
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