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Conformational detection of p53's oligomeric state by FlAsH Fluorescence

The p53 tumor suppressor protein is a critical checkpoint in prevention of tumor formation, and the function of p53 is dependent on proper formation of the active tetramer. In vitro studies have shown that p53 binds DNA most efficiently as a tetramer, though inactive p53 is predicted to be monomeric...

詳細記述

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書誌詳細
主要な著者: Webber, Tawnya M., Allen, Andrew C., Ma, Wai Kit, Molloy, Rhett G., Kettelkamp, Charisse N., Dow, Caitlin A., Gage, Matthew J.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743378/
https://ncbi.nlm.nih.gov/pubmed/19393630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.04.073
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