Conformational detection of p53's oligomeric state by FlAsH Fluorescence

The p53 tumor suppressor protein is a critical checkpoint in prevention of tumor formation, and the function of p53 is dependent on proper formation of the active tetramer. In vitro studies have shown that p53 binds DNA most efficiently as a tetramer, though inactive p53 is predicted to be monomeric...

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Main Authors: Webber, Tawnya M., Allen, Andrew C., Ma, Wai Kit, Molloy, Rhett G., Kettelkamp, Charisse N., Dow, Caitlin A., Gage, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743378/
https://ncbi.nlm.nih.gov/pubmed/19393630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.04.073
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