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Quantitation of Pyridyloxobutyl DNA Adducts in Nasal and Oral Mucosa of Rats Treated Chronically with Enantiomers of N′-nitrosonornicotine
N′-nitrosonornicotine (NNN) is one of the most important strong carcinogens in tobacco products, and is believed to play a significant role in the induction of esophageal cancer in smokers and oral cavity cancer in snuff dippers. NNN is metabolically activated through cytochrome P450-catalyzed α-hyd...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743010/ https://ncbi.nlm.nih.gov/pubmed/19405515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900040j |
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