Molecular Requirements for Recognition of Brain Voltage-gated Sodium Channels by Scorpion α-Toxins

The scorpion α-toxin Lqh2 (from Leiurus quinquestriatus hebraeus) is active at various mammalian voltage-gated sodium channels (Na(v)s) and is inactive at insect Na(v)s. To resolve the molecular basis of this preference we used the following strategy: 1) Lqh2 was expressed in recombinant form and ke...

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Bibliographic Details
Main Authors: Kahn, Roy, Karbat, Izhar, Ilan, Nitza, Cohen, Lior, Sokolov, Stanislav, Catterall, William A., Gordon, Dalia, Gurevitz, Michael
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742833/
https://ncbi.nlm.nih.gov/pubmed/19509294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.021303
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