The Impact of Individual Human Immunodeficiency Virus Type 1 Protease Mutations on Drug Susceptibility Is Highly Influenced by Complex Interactions with the Background Protease Sequence

The requirement for multiple mutations for protease inhibitor (PI) resistance necessitates a better understanding of the molecular basis of resistance development. The novel bioinformatics resistance determination approach presented here elaborates on genetic profiles observed in clinical human immu...

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Detaylı Bibliyografya
Asıl Yazarlar: Van Marck, H., Dierynck, I., Kraus, G., Hallenberger, S., Pattery, T., Muyldermans, G., Geeraert, L., Borozdina, L., Bonesteel, R., Aston, C., Shaw, E., Chen, Q., Martinez, C., Koka, V., Lee, J., Chi, E., de Béthune, M.-P., Hertogs, K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2009
Konular:
Vaccines and Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738252/
https://ncbi.nlm.nih.gov/pubmed/19587054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00291-09
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