The Impact of Individual Human Immunodeficiency Virus Type 1 Protease Mutations on Drug Susceptibility Is Highly Influenced by Complex Interactions with the Background Protease Sequence

The requirement for multiple mutations for protease inhibitor (PI) resistance necessitates a better understanding of the molecular basis of resistance development. The novel bioinformatics resistance determination approach presented here elaborates on genetic profiles observed in clinical human immu...

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Main Authors: Van Marck, H., Dierynck, I., Kraus, G., Hallenberger, S., Pattery, T., Muyldermans, G., Geeraert, L., Borozdina, L., Bonesteel, R., Aston, C., Shaw, E., Chen, Q., Martinez, C., Koka, V., Lee, J., Chi, E., de Béthune, M.-P., Hertogs, K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738252/
https://ncbi.nlm.nih.gov/pubmed/19587054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00291-09
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