TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors

TMC310911 is a novel human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI) structurally closely related to darunavir (DRV) but with improved virological characteristics. TMC310911 has potent activity against wild-type (WT) HIV-1 (median 50% effective concentration [EC(50)], 14 nM) and...

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Bibliografische gegevens
Hoofdauteurs: Dierynck, Inge, Van Marck, Herwig, Van Ginderen, Marcia, Jonckers, Tim H. M., Nalam, Madhavi N. L., Schiffer, Celia A., Raoof, Araz, Kraus, Guenter, Picchio, Gaston
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2011
Onderwerpen:
Antiviral Agents
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232804/
https://ncbi.nlm.nih.gov/pubmed/21896904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00748-11
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