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Binding Kinetics of Darunavir to Human Immunodeficiency Virus Type 1 Protease Explain the Potent Antiviral Activity and High Genetic Barrier

The high incidence of cross-resistance between human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) limits their sequential use. This necessitates the development of PIs with a high genetic barrier and a broad spectrum of activity against PI-resistant HIV, such as tipranavir and dar...

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書誌詳細
主要な著者: Dierynck, Inge, De Wit, Mieke, Gustin, Emmanuel, Keuleers, Inge, Vandersmissen, Johan, Hallenberger, Sabine, Hertogs, Kurt
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168871/
https://ncbi.nlm.nih.gov/pubmed/17928344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01184-07
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