Binding Kinetics of Darunavir to Human Immunodeficiency Virus Type 1 Protease Explain the Potent Antiviral Activity and High Genetic Barrier

par Dierynck, Inge, De Wit, Mieke, Gustin, Emmanuel, Keuleers, Inge, Vandersmissen, Johan, Hallenberger, Sabine, Hertogs, Kurt
Publié 2007

Ellipsoid Segmentation Model for Analyzing Light-Attenuated 3D Confocal Image Stacks of Fluorescent Multi-Cellular Spheroids

par Barbier, Michaël, Jaensch, Steffen, Cornelissen, Frans, Vidic, Suzana, Gjerde, Kjersti, de Hoogt, Ronald, Graeser, Ralph, Gustin, Emmanuel, Chong, Yolanda T.
Publié dans PLoS One (2016)

Repurposing high-throughput image assays enables biological activity prediction for drug discovery

par Simm, Jaak, Klambauer, Günter, Arany, Adam, Steijaert, Marvin, Wegner, Jörg Kurt, Gustin, Emmanuel, Chupakhin, Vladimir, Chong, Yolanda T., Vialard, Jorge, Buijnsters, Peter, Velter, Ingrid, Vapirev, Alexander, Singh, Shantanu, Carpenter, Anne E., Wuyts, Roel, Hochreiter, Sepp, Moreau, Yves, Ceulemans, Hugo
Publié dans Cell Chem Biol (2018)

Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines

par Cox, Michael J., Jaensch, Steffen, Van de Waeter, Jelle, Cougnaud, Laure, Seynaeve, Daan, Benalla, Soulaiman, Koo, Seong Joo, Van Den Wyngaert, Ilse, Neefs, Jean-Marc, Malkov, Dmitry, Bittremieux, Mart, Steemans, Margino, Peeters, Pieter J., Wegner, Jörg Kurt, Ceulemans, Hugo, Gustin, Emmanuel, Chong, Yolanda T., Göhlmann, Hinrich W. H.
Publié dans Sci Rep (2020)