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Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

Mitochondrial outer membrane permeabilisation (MOMP) is the point of no return in many forms of apoptotic cell death. The killing effect of MOMP is twofold; it both initiates a proteolytic cascade of pro-apoptotic enzymes and damages mitochondrial function. Accordingly, prevention of MOMP can rescue...

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Bibliografski detalji
Glavni autori: Dewson, Grant, Kluck, Ruth M.
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736138/
https://ncbi.nlm.nih.gov/pubmed/19795525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.038166
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