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Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

Mitochondrial outer membrane permeabilisation (MOMP) is the point of no return in many forms of apoptotic cell death. The killing effect of MOMP is twofold; it both initiates a proteolytic cascade of pro-apoptotic enzymes and damages mitochondrial function. Accordingly, prevention of MOMP can rescue...

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Bibliografiske detaljer
Main Authors: Dewson, Grant, Kluck, Ruth M.
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736138/
https://ncbi.nlm.nih.gov/pubmed/19795525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.038166
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