Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair

Based on the crystal structure of human DNA ligase I complexed with nicked DNA, computer-aided drug design was used to identify compounds in a database of 1.5 million commercially available low molecular weight chemicals that were predicted to bind to a DNA binding pocket within the DNA binding doma...

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Bibliografiske detaljer
Main Authors: Chen, Xi, Zhong, Shijun, Zhu, Xiao, Dziegielewska, Barbara, Ellenberger, Tom, Wilson, Gerald M., MacKerell, Alexander D., Tomkinson, Alan E.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734474/
https://ncbi.nlm.nih.gov/pubmed/18451142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6636
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