Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design

Linking together of DNA strands by DNA ligases is essential for DNA replication and repair. Since many therapies used to treat cancer act by causing DNA damage, there is growing interest in the development of DNA repair inhibitors. Accordingly, virtual database screening and experimental evaluation...

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Main Authors: Zhong, Shijun, Chen, Xi, Zhu, Xiao, Dziegielewska, Barbara, Bachman, Kurtis E., Ellenberger, Tom, Ballin, Jeff D., Wilson, Gerald M., Tomkinson, Alan E., MacKerell, Alexander D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788817/
https://ncbi.nlm.nih.gov/pubmed/18630893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8001668
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