Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design

Linking together of DNA strands by DNA ligases is essential for DNA replication and repair. Since many therapies used to treat cancer act by causing DNA damage, there is growing interest in the development of DNA repair inhibitors. Accordingly, virtual database screening and experimental evaluation...

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Bibliografische gegevens
Hoofdauteurs: Zhong, Shijun, Chen, Xi, Zhu, Xiao, Dziegielewska, Barbara, Bachman, Kurtis E., Ellenberger, Tom, Ballin, Jeff D., Wilson, Gerald M., Tomkinson, Alan E., MacKerell, Alexander D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788817/
https://ncbi.nlm.nih.gov/pubmed/18630893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8001668
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