Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design

Linking together of DNA strands by DNA ligases is essential for DNA replication and repair. Since many therapies used to treat cancer act by causing DNA damage, there is growing interest in the development of DNA repair inhibitors. Accordingly, virtual database screening and experimental evaluation...

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Bibliographic Details
Main Authors: Zhong, Shijun, Chen, Xi, Zhu, Xiao, Dziegielewska, Barbara, Bachman, Kurtis E., Ellenberger, Tom, Ballin, Jeff D., Wilson, Gerald M., Tomkinson, Alan E., MacKerell, Alexander D.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788817/
https://ncbi.nlm.nih.gov/pubmed/18630893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8001668
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