Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design

Linking together of DNA strands by DNA ligases is essential for DNA replication and repair. Since many therapies used to treat cancer act by causing DNA damage, there is growing interest in the development of DNA repair inhibitors. Accordingly, virtual database screening and experimental evaluation...

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Bibliografiske detaljer
Main Authors: Zhong, Shijun, Chen, Xi, Zhu, Xiao, Dziegielewska, Barbara, Bachman, Kurtis E., Ellenberger, Tom, Ballin, Jeff D., Wilson, Gerald M., Tomkinson, Alan E., MacKerell, Alexander D.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788817/
https://ncbi.nlm.nih.gov/pubmed/18630893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8001668
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