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Molecular determinants of fast Ca(2+)-dependent inactivation and gating of the Orai channels

Ca(2+) influx by store-operated Ca(2+) influx channels (SOCs) mediates many cellular functions regulated by Ca(2+), and excessive SOC-mediated Ca(2+) influx is cytotoxic and associated with disease. One form of SOC is the CRAC current that is mediated by Orai channels activated by STIM1. A fundament...

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Autors principals: Lee, Kyu Pil, Yuan, Joseph P., Zeng, Weizhong, So, Insuk, Worley, Paul F., Muallem, Shmuel
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732841/
https://ncbi.nlm.nih.gov/pubmed/19706554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904664106
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